Endocrine Abstracts

Nesfatin-1, product of the precursor NEFA/nucleobindin 2 (NUCB2), was initially identified as anorectic hypothalamic neuropeptide, acting in a leptin-independent manner. In addition to its central role in the control of energy homeostasis, evidence has mounted recently that nesfatin-1 is also produced in peripheral metabolic tissues, such as pancreas, adipose and gut. Moreover, nesfatin-1 has been shown to participate in the control of body functions gated by whole-body energy...